2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-124540B
    (Rac)-ABT-202 dihydrochloride 1258641-38-1 98.79%
    (Rac)-ABT-202 dihydrochloride is a racemate of ABT-202. ABT-202 is an agonist of nicotinic acetylcholine receptors (nAChRs) and can be used as an analgesic.
    (Rac)-ABT-202 dihydrochloride
  • HY-155612A
    (Rac)-M826 2649883-37-2 99.75%
    (Rac)-M826 is the racemate of M826 (HY-155612). M826 is a selective and reversible inhibitor for caspase-3 with an IC50 of 0.005 μM. M826 inhibits apoptosis in cell NT2. M826 can be used for nervous system diseases research.
    (Rac)-M826
  • HY-164795A
    SBI-810 hydrochloride 2772746-58-2 99.55%
    SBI-810 hydrochloride is a functionally selected β-arrestin-biased neurotensin receptor 1 (NTSR1) allosteric modulator. SBI-810 hydrochloride modulates NTSR1 G protein signaling in a G protein-specific manner in the presence of the endogenous ligand, neurotensin (NT). SBI-810 hydrochloride fully antagonizes NT-induced activation of Gq, partially antagonizes NT-induced activation of Gi1 and is permissive of NTSR1 activation of GoA and G12.
    SBI-810 hydrochloride
  • HY-B0158S7
    Cytidine-13C9
    Cytidine-13C9 (Cytosine β-D-riboside-13C9; Cytosine-1-β-D-ribofuranoside-13C9) is 13C labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function.
    Cytidine-13C9
  • HY-B0166S1
    L-Ascorbic acid-13C 178101-88-7 ≥98.0%
    L-Ascorbic acid-13C is the 13C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells.
    L-Ascorbic acid-13C
  • HY-N0067S3
    γ-Aminobutyric acid-13C4 ≥99.0%
    γ-Aminobutyric acid-13C4 is the 13C-labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors).
    γ-Aminobutyric acid-13C4
  • HY-N0473S3
    L-Tyrosine-13C9 55443-60-2 99.81%
    L-Tyrosine-13C9 is the 13C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
    L-Tyrosine-13C9
  • HY-N0473S9
    L-Tyrosine-d7 130551-49-4 99.77%
    L-Tyrosine-d7 is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
    L-Tyrosine-d7
  • HY-P10234A
    Poneratoxin acetate 98.77%
    Poneratoxin acetate is the acetate salt form of Poneratoxin (HY-P10234). Poneratoxin acetate is the modulator for voltage-gated sodium channel (NaV, EC50 for NaV1.6 and NaV1.7 is 97 nM and 2.3 µM), that lowers the voltage threshold for activation and inhibits the inactivation of channels, enhances the excitability of neurons, and leads to the transmission of pain signals.
    Poneratoxin acetate
  • HY-P991045
    Donanemab (Mouse IgG2a) 99%
    Donanemab (Mouse IgG2a) (mE8-IgG2a) is a mouse-derived IgG2 monoclonal antibody used in the research of Alzheimer's disease.
    Donanemab (Mouse IgG2a)
  • HY-W007524
    2-Aminoquinoline 580-22-3 ≥98.0%
    2-Aminoquinoline (2-Quinolinamine) is a promising compound as bioavailable nNOS inhibitor but suffers from low human nNOS inhibition, low selectivity versus human eNOS, and significant binding to other CNS targets. 2-Aminoquinoline exhibits antiviral activity against the vaccinia virus. 2-Aminoquinoline has the potential for the research of antineurodegenerative agents.
    2-Aminoquinoline
  • HY-W007880
    (R)-D2PM 22348-32-9 99.93%
    (R)-D2PM ((R)-Diphenylprolinol) is an isomer of the psychoactive substance D2PM and a pyrrolidine analog.
    (R)-D2PM
  • HY-W041333
    Phenibut hydrochloride 3060-41-1 ≥98.0%
    Phenibut (β-Phenyl-GABA) hydrochloride is an orally active GABA-B agonist. Phenibut hydrochloride acts as a GABA-mimetic, primarily at GABAB?receptors. Phenibut hydrochloride has anxiolytic and nootropic (cognition enhancing) effects.
    Phenibut hydrochloride
  • HY-W042156
    Aegeline 456-12-2 99.95%
    Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity.
    Aegeline
  • HY-W052508
    Norquetiapine 5747-48-8 99.95%
    Norquetiapine is an antidepressant and neuroprotective agent and is the active metabolic component of Quetiapine (HY-14544). Norquetiapine is also a partial 5-HT1A receptor agonist, and a presynaptic α2, 5-HT2C and 5-HT7 b> Receptor antagonist. Norquetiapine can also selectively inhibit norepinephrine transporter (NET), inhibit norepinephrine reuptake, and has potential inhibitory effects on bipolar depression, major depressive disorder, and generalized anxiety disorder. Norquetiapine demonstrated in vivo activity in forced swimming in mice and learned helplessness tests in rats.
    Norquetiapine
  • HY-W453397
    Aberrant tau ligand 1 1892461-96-9 ≥98.0%
    Aberrant tau ligand 1 is a ligand for tau proteins with abnormal forms. Aberrant tau ligand 1 can be used for synthesis of PROTAC aberrant Tau degrader QC-01-175 (HY-134850).
    Aberrant tau ligand 1
  • HY-W742957
    Pregnanolone sulfate (pyridinium) 124107-39-7 99.78%
    Pregnanolone sulfate pyridinium is an endogenous neurosteroid that inhibits NMDA receptors and is neuroprotective.
    Pregnanolone sulfate (pyridinium)
  • HY-113468AS
    3-O-Methyldopa-d3 586954-09-8 ≥99.0%
    3-O-Methyldopa-d3 (3-Methoxy-L-tyrosine-d3) is deuterium labeled 3-O-Methyldopa (HY-113468A). 3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA (HY-N0304) that can cross the blood-brain barrier (BBB). 3-O-Methyldopa inhibits the astrocyte-mediated protective effect of L-DOPA (HY-N0304) on dopaminergic neurons. In addition, 3-O-Methyldopa has certain antidepressant and neuroprotective activities. 3-O-Methyldopa can be used in the research of nervous system diseases such as depression and Parkinson's disease.
    3-O-Methyldopa-d3
  • HY-B0451AS7
    Dopamine-d5 hydrochloride 2193106-55-5 ≥99.0%
    Dopamine-d5 (hydrochloride) is the deuterium labeled Dopamine (hydrochloride). Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis.
    Dopamine-d5 hydrochloride
  • HY-W011051S
    2-Arachidonoylglycerol-d8 924894-97-3 ≥98.0%
    2-Arachidonoylglycerol-d8 is the deuterium labeled 2-Arachidonoylglycerol. 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand in the central nervous system.
    2-Arachidonoylglycerol-d8
Cat. No. Product Name / Synonyms Application Reactivity